| Rank | Movie Title (click to view) | Studio | Total Gross / Theaters | Opening / Theaters | Open |
| 1 | Spider-Man | Sony | $403,706,375 | 3,876 | $114,844,116 | 3,615 | 5/3/02 |
| 2 | Spider-Man 2 | Sony | $373,585,825 | 4,166 | $88,156,227 | 4,152 | 6/30/04 |
| 3 | Spider-Man 3 | Sony | $336,530,303 | 4,324 | $151,116,516 | 4,252 | 5/4/07 |
| 4 | Skyfall | Sony | $304,360,277 | 3,526 | $88,364,714 | 3,505 | 11/9/12 |
| 5 | The Amazing Spider-Man | Sony | $262,030,663 | 4,318 | $62,004,688 | 4,318 | 7/3/12 |
| 6 | Men in Black | Sony | $250,690,539 | 3,180 | $51,068,455 | 3,020 | 7/2/97 |
| 7 | Ghostbusters | Col. | $229,242,989 | 1,506 | $13,578,151 | 1,339 | 6/8/84 |
| 8 | Hancock | Sony | $227,946,274 | 3,965 | $62,603,879 | 3,965 | 7/2/08 |
| 9 | The Da Vinci Code | Sony | $217,536,138 | 3,757 | $77,073,388 | 3,735 | 5/19/06 |
| 10 | Terminator 2: Judgment Day | TriS | $204,843,345 | 2,495 | $31,765,506 | 2,274 | 7/3/91 |
| 11 | Men in Black II | Sony | $190,418,803 | 3,641 | $52,148,751 | 3,557 | 7/3/02 |
| 12 | Hitch | Sony | $179,495,555 | 3,575 | $43,142,214 | 3,575 | 2/11/05 |
| 13 | MIB 3 | Sony | $179,020,854 | 4,248 | $54,592,779 | 4,248 | 5/25/12 |
| 14 | Tootsie | Col. | $177,200,000 | 1,222 | $5,540,470 | 943 | 12/17/82 |
| 15 | The Karate Kid | Sony | $176,591,618 | 3,740 | $55,665,805 | 3,663 | 6/11/10 |
| 16 | Air Force One | Sony | $172,956,409 | 2,981 | $37,132,505 | 2,919 | 7/25/97 |
| 17 | Quantum of Solace | Sony | $168,368,427 | 3,501 | $67,528,882 | 3,451 | 11/14/08 |
| 18 | Casino Royale | Sony | $167,445,960 | 3,443 | $40,833,156 | 3,434 | 11/17/06 |
| 19 | 2012 | Sony | $166,112,167 | 3,444 | $65,237,614 | 3,404 | 11/13/09 |
| 20 | The Pursuit of Happyness | Sony | $163,566,459 | 3,169 | $26,541,709 | 2,852 | 12/15/06 |
| 21 | Big Daddy | Sony | $163,479,795 | 3,254 | $41,536,370 | 3,027 | 6/25/99 |
| 22 | Grown Ups | Sony | $162,001,186 | 3,534 | $40,506,562 | 3,534 | 6/25/10 |
| 23 | Jerry Maguire | Sony | $153,952,592 | 2,531 | $17,084,296 | 2,531 | 12/13/96 |
| 24 | Rambo: First Blood Part II | TriS | $150,415,432 | 2,074 | $20,176,217 | 2,074 | 5/22/85 |
| 25 | As Good as It Gets | Sony | $148,478,011 | 1,837 | $12,606,928 | 1,572 | 12/23/97 |
| 26 | Hotel Transylvania | Sony | $148,313,048 | 3,375 | $42,522,194 | 3,349 | 9/28/12 |
| 27 | Talladega Nights: The Ballad of Ricky Bobby | Sony | $148,213,377 | 3,807 | $47,042,215 | 3,803 | 8/4/06 |
| 28 | Paul Blart: Mall Cop | Sony | $146,336,178 | 3,206 | $31,832,636 | 3,144 | 1/16/09 |
| 29 | The Smurfs | Sony | $142,614,158 | 3,427 | $35,611,637 | 3,395 | 7/29/11 |
| 30 | XXX | SonR | $142,109,382 | 3,536 | $44,506,103 | 3,374 | 8/9/02 |
| 31 | A Few Good Men | Col. | $141,340,178 | 2,201 | $15,517,468 | 1,925 | 12/11/92 |
| 32 | Look Who's Talking | TriS | $140,088,813 | 1,651 | $12,107,784 | 1,208 | 10/13/89 |
| 33 | Stuart Little | Sony | $140,035,367 | 3,151 | $15,018,223 | 2,878 | 12/17/99 |
| 34 | Bad Boys II | Sony | $138,608,444 | 3,202 | $46,522,560 | 3,186 | 7/18/03 |
| 35 | 21 Jump Street | Sony | $138,447,667 | 3,148 | $36,302,612 | 3,121 | 3/16/12 |
| 36 | Click | SonR | $137,355,633 | 3,764 | $40,011,365 | 3,749 | 6/23/06 |
| 37 | Godzilla | Sony | $136,314,294 | 3,310 | $44,047,541 | 3,310 | 5/20/98 |
| 38 | Anger Management | SonR | $135,645,823 | 3,656 | $42,220,847 | 3,551 | 4/11/03 |
| 39 | Angels & Demons | Sony | $133,375,846 | 3,527 | $46,204,168 | 3,527 | 5/15/09 |
| 40 | My Best Friend's Wedding | Sony | $127,120,029 | 2,376 | $21,678,377 | 2,134 | 6/20/97 |
| 41 | Sleepless in Seattle | TriS | $126,680,884 | 1,657 | $17,253,733 | 1,579 | 6/25/93 |
| 42 | Mr. Deeds | Sony | $126,293,452 | 3,239 | $37,162,787 | 3,231 | 6/28/02 |
| 43 | Charlie's Angels | Sony | $125,305,545 | 3,037 | $40,128,550 | 3,037 | 11/3/00 |
| 44 | The Vow | SGem | $125,014,030 | 3,038 | $41,202,458 | 2,958 | 2/10/12 |
| 45 | Cloudy with a Chance of Meatballs | Sony | $124,870,275 | 3,119 | $30,304,648 | 3,119 | 9/18/09 |
| 46 | Something's Gotta Give | Sony | $124,728,738 | 2,876 | $16,064,723 | 2,677 | 12/12/03 |
| 47 | City Slickers | Col. | $124,033,791 | 2,171 | $13,032,121 | 1,992 | 6/7/91 |
| 48 | Superbad | Sony | $121,463,226 | 3,069 | $33,052,411 | 2,948 | 8/17/07 |
| 49 | 50 First Dates | Sony | $120,908,074 | 3,612 | $39,852,237 | 3,591 | 2/13/04 |
| 50 | Hook | TriS | $119,654,823 | 2,254 | $13,522,535 | 2,197 | 12/11/91 |
| 51 | Total Recall | Sony | $119,394,840 | 2,131 | $25,533,700 | 2,060 | 6/1/90 |
| 52 | The Other Guys | Sony | $119,219,978 | 3,651 | $35,543,162 | 3,651 | 8/6/10 |
| 53 | Salt | Sony | $118,311,368 | 3,612 | $36,011,243 | 3,612 | 7/23/10 |
| 54 | Basic Instinct | TriS | $117,727,224 | 1,884 | $15,129,385 | 1,567 | 3/20/92 |
| 55 | S.W.A.T. | Sony | $116,934,650 | 3,220 | $37,062,535 | 3,202 | 8/8/03 |
| 56 | Close Encounters of the Third Kind | Col. | $116,395,460 | 650 | $5,379,460 | 272 | 11/16/77 |
| 57 | Ghost Rider | Sony | $115,802,596 | 3,620 | $45,388,836 | 3,619 | 2/16/07 |
| 58 | District 9 | TriS | $115,646,235 | 3,180 | $37,354,308 | 3,049 | 8/14/09 |
| 59 | The Karate Kid Part II | Col. | $115,103,979 | 1,610 | $12,652,336 | 1,323 | 6/20/86 |
| 60 | The Patriot | Sony | $113,330,342 | 3,061 | $22,413,710 | 3,061 | 6/28/00 |
| 61 | Ghostbusters II | Col. | $112,494,738 | 2,410 | $29,472,894 | 2,410 | 6/16/89 |
| 62 | The Grudge | Sony | $110,359,362 | 3,348 | $39,128,715 | 3,245 | 10/22/04 |
| 63 | Fun with Dick and Jane | Sony | $110,332,737 | 3,239 | $14,383,515 | 3,056 | 12/21/05 |
| 64 | Black Hawk Down | SonR | $108,638,745 | 3,143 | $179,823 | 4 | 12/28/01 |
| 65 | A League of Their Own | Sony | $107,533,928 | 2,084 | $13,739,456 | 1,782 | 7/1/92 |
| 66 | Kramer Vs. Kramer | Col. | $106,260,000 | 898 | $5,531,000 | 524 | 12/19/79 |
| 67 | Daddy Day Care | SonR | $104,297,061 | 3,472 | $27,623,580 | 3,370 | 5/9/03 |
| 68 | Just Go With It | Sony | $103,028,109 | 3,548 | $30,514,732 | 3,548 | 2/11/11 |
| 69 | The Girl with the Dragon Tattoo (2011) | Sony | $102,515,793 | 2,950 | $12,768,604 | 2,914 | 12/21/11 |
| 70 | In the Line of Fire | Col. | $102,314,823 | 2,129 | $15,269,388 | 1,903 | 7/9/93 |
| 71 | Stir Crazy | Col. | $101,300,000 | N/A | $8,691,886 | 813 | 12/12/80 |
| 72 | Charlie's Angels: Full Throttle | Sony | $100,830,111 | 3,485 | $37,634,221 | 3,459 | 6/27/03 |
| 73 | Jumanji | Sony | $100,475,249 | 2,530 | $11,084,370 | 2,487 | 12/15/95 |
| 74 | Step Brothers | Sony | $100,468,793 | 3,182 | $30,940,732 | 3,094 | 7/25/08 |
| 75 | Bad Teacher | Sony | $100,292,856 | 3,049 | $31,603,106 | 3,049 | 6/24/11 |
| 76 | You Don't Mess with the Zohan | Sony | $100,018,837 | 3,466 | $38,531,374 | 3,462 | 6/6/08 |
| 77 | The Green Hornet | Sony | $98,780,042 | 3,584 | $33,526,876 | 3,584 | 1/14/11 |
| 78 | The Social Network | Sony | $96,962,694 | 2,921 | $22,445,653 | 2,771 | 10/1/10 |
| 79 | Panic Room | Sony | $96,397,334 | 3,119 | $30,056,751 | 3,053 | 3/29/02 |
| 80 | Zero Dark Thirty | Sony | $95,720,716 | 2,946 | $417,150 | 5 | 12/19/12 |
| 81 | Julie & Julia | Sony | $94,125,426 | 2,528 | $20,027,956 | 2,354 | 8/7/09 |
| 82 | The Mask of Zorro | Sony | $94,095,523 | 2,515 | $22,525,855 | 2,515 | 7/17/98 |
| 83 | Maid in Manhattan | SonR | $94,011,225 | 3,050 | $18,711,407 | 2,838 | 12/13/02 |
| 84 | America's Sweethearts | SonR | $93,607,673 | 3,011 | $30,181,877 | 3,011 | 7/20/01 |
| 85 | When Harry Met Sally... | Col. | $92,823,546 | 1,174 | $1,094,453 | 41 | 7/14/89 |
| 86 | Think Like a Man | SGem | $91,547,205 | 2,052 | $33,636,303 | 2,015 | 4/20/12 |
| 87 | Stepmom | Sony | $91,137,662 | 2,503 | $19,142,440 | 2,358 | 12/25/98 |
| 88 | The Karate Kid | Col. | $90,815,558 | 1,111 | $5,031,753 | 931 | 6/22/84 |
| 89 | The Ugly Truth | Sony | $88,915,214 | 2,975 | $27,605,576 | 2,882 | 7/24/09 |
| 90 | Pineapple Express | Sony | $87,341,380 | 3,072 | $23,245,025 | 3,072 | 8/6/08 |
| 91 | Stripes | Col. | $85,297,000 | N/A | $6,130,197 | 1,074 | 6/26/81 |
| 92 | Open Season | Sony | $85,105,259 | 3,833 | $23,624,548 | 3,833 | 9/29/06 |
| 93 | Cliffhanger | TriS | $84,049,211 | 2,431 | $16,176,967 | 2,333 | 5/28/93 |
| 94 | Steel Magnolias | TriS | $83,759,091 | 1,372 | $5,425,440 | 480 | 11/17/89 |
| 95 | Battle: Los Angeles | Sony | $83,552,429 | 3,417 | $35,573,187 | 3,417 | 3/11/11 |
| 96 | Are We There Yet? | SonR | $82,674,398 | 2,810 | $18,575,214 | 2,709 | 1/21/05 |
| 97 | Bram Stoker's Dracula | Col. | $82,522,790 | 2,491 | $30,521,679 | 2,491 | 11/13/92 |
| 98 | The Pink Panther (2006) | Sony | $82,226,474 | 3,477 | $20,220,412 | 3,477 | 2/10/06 |
| 99 | 21 | Sony | $81,159,365 | 2,952 | $24,105,943 | 2,648 | 3/28/08 |
| 100 | Eat Pray Love | Sony | $80,574,010 | 3,108 | $23,104,523 | 3,082 | 8/13/10 |
| Summary of 823 Movies on Chart: |
| Totals: | $29,528,489,077 | - | - | - | - |
| Averages: | $35,879,088 | - | - | - | - |
 |
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